Antibacterial activity
Polymyxin B: effective against gram-negative (eg: P. aeruginosa)
Bacitracin: effective against a variety of gram-positive cocci and bacilli
Pregnancy Risk Factor
Class C
Contraindication/Precaution
Hypersensitivity to polymyxin B or bacitracin or any component
Mechanism of Action
Polymyxin B: behave as cationic, surface-active compounds that disrupt the permeability of both the outer and the cytoplasmic membranes of gram-negative bacteria.
Bacitracin: inhibits bacterial cell wall synthesis
Pharmacodynamics
Metabolism: N/A
Half-life: 5 hours, changes with renal function
Elimination: excreted in urine
Dosage
Topical:
Children and adults:
apply qd-qid
Ophthalmic: ointment
Children and adults:
apply 2 cm ribbon OS/OD q3-8h
Dose VS renal function
Cr. clearance
N/A
Dialysis
Hemo: N/A
CAPD: N/A
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