Saturday, November 19, 2011


Antibacterial activity

Cephalosporin, third generation
Effective against gram negative (except: P. aeruginosa & Enterobacter sp)
Gram-positive coverage (
Limited anaerobic coverage 

Pregnancy Risk Factor

Class B


Hypersensitivity to cefdinir, other cephalosporins or any component
Use caution if previous penicillins hypersensitivity:  10% of patient may have cross-hypersensitivity to cephalosporins
Use caution if renal dysfunction 
Not recommended in children <6 month of age. Mechanism of Action Inhibits cell wall synthesis (bactericidal) Pharmacodynamics Metabolism: N/A Half-life: 1.7 hours, changes with renal function Elimination: excreted in urine Dosage Children:   >6 month olds: (max: 600 mg/d)
7 mg/kg PO q12h or
14 mg/kg PO qd


300 mg PO bid or
600 mg PO qd

Dose VS renal function

Cr. clearance (ml/min):
<30: 7 mg/kg (max 300 mg/dose)  PO qd >30: unchanged

Hemo: give 7 mg/kg (max 300 mg/dose)  PO x1 after dialysis then q48h

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