CEFPROZIL

Antibacterial activity

Cephalosporins, second generation
Effective against some gram-negative
Gram-positive coverage 
Anaerobic coverage (no B. fragilis coverage)

Pregnancy Risk Factor

Class B

Contraindication/Precaution

Hypersensitivity to cefprozil, other cephalosporins or any component
Do not use suspension if phenylketonuria
Use caution if previous penicillins hypersensitivity:  10% of patient may have cross-hypersensitivity to cephalosporins
Use caution with nursing mothers
Use caution if seizure disorder
Use caution if renal dysfunction or if other nephrotoxic agents present
Use caution if history of ATB related colitis
Safety and effectiveness for use in children <6 months old have not been established Mechanism of Action Inhibits cell wall synthesis (bactericidal) Pharmacodynamics Metabolism: liver Half-life: 1.3 hours, changes with renal function Elimination: excreted in urine Dosage Children: (max 1 g/day) >6 months old: 
15-30 mg/kg/d PO div bid

Adults: (max 1 g/day)

Bacterial infections:
250-500 mg PO q12-24h

Dose VS renal function

Cr. clearance (ml/min):
<30: 50% of usual dose q12-24h >30: unchanged

Dialysis
Hemo: 50% of usual dose post-dialysis
CAPD: N/A