Saturday, November 19, 2011


Antibacterial activity

Cephalosporins, first generation
Gram-positive cocci (except ORSA/MRSA and enteroccocus species)
Gram negative bacilli ( E. coli, klebsiella, p. mirabillis)

Pregnancy Risk Factor

Class B


Hypersensitivity to cephalexin, other cephalosporins or any component
Use caution if previous penicillins hypersensitivity:  10% of patient may have cross-hypersensitivity to cephalosporins
Use caution if seizure disorder
Use caution with nursing mothers
Use caution if renal dysfunction or if other nephrotoxic agents present
Use caution if history of ATB related colitis
Safety and effectiveness for use in infants <1 month of age have not been established Mechanism of Action Inhibits cell wall synthesis (bactericidal) Pharmacodynamics Metabolism: N/A Half-life: 0.5-1.2 hours, changes with renal function Elimination: excreted in urine Dosage Children: (max 4 g/d) > 28 days old: 
25-50 mg/kg/d PO div qid


Bacterial infections:
250-1000 mg PO q6h

Dose VS renal function

Cr. clearance (ml/min):
<10: 250 mg PO q12-24h 10-50: 250-500 q8-12h 50-80: unchanged >80: unchanged

Hemo: 0.25-1g PO post dialysis

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