Antibacterial activity
Cephalosporins, first generation
Gram-positive cocci (except ORSA/MRSA and enteroccocus species)
Gram negative bacilli ( E. coli, klebsiella, p. mirabillis)
Pregnancy Risk Factor
Class B
Contraindication/Precaution
Hypersensitivity to cephalexin, other cephalosporins or any component
Use caution if previous penicillins hypersensitivity: 10% of patient may have cross-hypersensitivity to cephalosporins
Use caution if seizure disorder
Use caution with nursing mothers
Use caution if renal dysfunction or if other nephrotoxic agents present
Use caution if history of ATB related colitis
Safety and effectiveness for use in infants <1 month of age have not been established
Mechanism of Action
Inhibits cell wall synthesis (bactericidal)
Pharmacodynamics
Metabolism: N/A
Half-life: 0.5-1.2 hours, changes with renal function
Elimination: excreted in urine
Dosage
Children: (max 4 g/d)
> 28 days old:
25-50 mg/kg/d PO div qid
Adults:
Bacterial infections:
250-1000 mg PO q6h
Dose VS renal function
Cr. clearance (ml/min):
<10: 250 mg PO q12-24h
10-50: 250-500 q8-12h
50-80: unchanged
>80: unchanged
Dialysis
Hemo: 0.25-1g PO post dialysis
CAPD: N/A
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