Antibacterial Activity
Effective against Gram-positive cocci including the b-lactamase producers
Effective against some streptococci
Not effective against gram-negative & anaerobes
Pregnancy Risk Factor
Category B
Contraindication/Precaution
Hypersensitivity to cloxacillin or any penicillins or any component
Use caution with patient who are allergic to cephalosporin, they could have an hypersensibility to penicillins
Use caution if impaired liver/renal function
Mechanism of Action
Selective inhibitors of bacterial cell wall synthesis, by inhibiting to penicillins binding proteins (PBP'S)
Pharmacodynamics/Kinetics
Metabolism:
Partially by the kidney
Half-life:
0.5-1.5 hours, change with renal/hepatic function.
Elimination:
mostly excreted in urine, and some in feces
Dosage
Children: (max 4g/day)
> 28 days old: 50-100 mg/kg/d IV/PO div qid
Adults:
250-500 mg q6h IV/PO
Dosage In Renal Failure
Creatinine clearance (ml/min):
10: unchanged
10-50: unchanged
50-80: unchanged
>80: unchanged
Dialysis
Hemo: N/A
CAPD: N/A
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