Indicated in Rx of aspergillosis or any type of progressive fungal infection in patients who are refractory to or intolerant of conventional amphotericin B therapy
Effective against Candida sp. and Aspergillus sp.
Active in animal models against Aspergillus fumigatus, Candida albicans. C. guillermondii, C. stellatoideae, C. tropicalis, Cryptococcus sp., Coccidioidomyces sp., Histoplasma sp., and Blastomyces sp
Pregnancy Risk Factor
Hypersensitivity to amphotericin , or any component
Anaphylaxis has been reported; facilities for cardiopulmonary resuscitation should be available
Should not be use while nursing
Use caution if impaired renal function
Overdose has been reported to result in cardio-respiratory arrest.
Mechanism of Action
Fungistatic or fungicidal depending on the concentration in body fluids and the susceptibility of the fungus.
Acts by binding to sterols in the cell membrane of susceptible fungi with a resultant change in membrane permeability allowing leakage of intercellular components.
Half-life: ~24 hours, changes with renal function:
Elimination: excreted in urine
Children and Adults:
2.5-5 mg/kg IV qd as a single infusion at rate of 2.5mg/kg/h
Dose VS renal function
Cr. clearance (ml/min):
<10: give q24h
10-50: give q24h
50-80: give q24h
>80: give q24h
CAPD: give q24h