CEFTAZIDIME

Antibacterial activity

Cephalosporin, third generation
Effective against most gram-negative 
Gram-positive coverage (eg. Strep sp. and Staph aureus/epidermidis)
Limited anaerobic coverage

Pregnancy Risk Factor

Class B

Contraindication/Precaution

Hypersensitivity to ceftazidime, other cephalosporins or any component
Use caution if previous penicillins hypersensitivity:  10% of patient may have cross-hypersensitivity to cephalosporins
Use caution with nursing mothers
Use caution if seizure disorder
Use caution if renal dysfunction or if other nephrotoxic agents present
Use caution if history of ATB related colitis

Mechanism of Action

Inhibits cell wall synthesis (bactericidal)

Pharmacodynamics

Metabolism: N/A
Half-life:1.9 hours, changes with renal function
Elimination: excreted in urine

Dosage

Children: (max 6g/day)

Body weight < 2000 g 0-7 days old: 50 mg/kg IM/IV q12h 8-28 days old: 50 mg/kg g IM/IV q 8h Body weight > 2000 g
0-7 days old: 33 mg/kg g IM/IV q 8h
8-28 days old: 50 mg/kg g IM/IV q 8h
> 28 days old: 50 mg/kg g IM/IV q 8h

Adults: (max 6g/day)

250-2000 mg IM/IV q8-12h

Dose VS renal function

Cr. clearance (ml/min):
<10: 0.5-1 g IM/IV q48h 10-50: 1 g IM/IV q24-48h 50-80: unchanged >80: unchanged

Dialysis
Hemo: 1 g IM/IV post dialysis
CAPD: 500 mg IM/IV qd