CEFOXITIN

Antibacterial activity

Cephalosporins, second generation
Effective against some gram-negative
Gram-positive coverage 
Good anaerobic coverage (no C. difficile coverage)

Pregnancy Risk Factor

Class B

Contraindication/Precaution

Hypersensitivity to cefoxitin, other cephalosporins or any component
Use caution if previous penicillins hypersensitivity:  10% of patient may have cross-hypersensitivity to cephalosporins
Use caution with nursing mothers
Use caution if renal dysfunction or if other nephrotoxic agents present
Use caution if history of ATB related colitis
Safety and effectiveness for use in children <3 months old have not been established Mechanism of Action Inhibits cell wall synthesis (bactericidal) Pharmacodynamics Metabolism: N/A Half-life: 41-59 minutes, changes with renal function Elimination: excreted in urine Dosage Children: (max 12g/day) >3 months old: 
80-160 mg/kg/d IV div q4-6h

Adults: (max 12 g/day)

Bacterial infections:
1-2 g IV q6-8h
Prophylaxis: 
2 g IV x 1 given  30-60 min before surgery then 1 dose post-op

Dose VS renal function

Cr. clearance (ml/min):
<10: 0.5-1 g IV q24-48h 10-50: 1-2g IV q12-24h 50-80: 1-2 g IV q8-12h >80: unchanged

Dialysis
Hemo: 1-2 g IV post-dialysis
CAPD: N/A