CEFPODOXIME

Antibacterial activity

Cephalosporin, third generation
Effective against gram-negative 
Gram-positive coverage 
Limited anaerobic coverage (P. magnus only)

Pregnancy Risk Factor

Class B

Contraindication/Precaution

Hypersensitivity to cefpodoxime, other cephalosporins or any component
Use caution if previous penicillins hypersensitivity:  10% of patient may have cross-hypersensitivity to cephalosporins
Use caution with nursing mothers
Use caution if renal dysfunction
Use caution if history of ATB related colitis
Safety and efficacy in infant less than 2 months old have not been established

Mechanism of Action

Inhibits cell wall synthesis (bactericidal)

Pharmacodynamics

Metabolism: minimal
Half-life: 2.09-2.84 hours, changes with hepatic function
Elimination: excreted in urine

Dosage

Children: (max 400 mg/day)

> 2 months old:  
5 mg/kg PO bid

Adults:

100-400 mg PO q12h

Dose VS renal function

Cr. clearance (ml/min):
<30: same dose but q24h >30: unchanged
Dialysis
Hemo:  100-400 mg PO 3x/week
CAPD: N/A