CEFPIROME

Antibacterial activity

Cephalosporin, third generation (sometime refer to as fourth generation)
Effective against gram-negative 
Gram-positive coverage
Limited anaerobic coverage 

Pregnancy Risk Factor

Class B

Contraindication/Precaution

Hypersensitivity to cefpirome, other cephalosporins or any component
Use caution if previous penicillins hypersensitivity:  10% of patient may have cross-hypersensitivity to cephalosporins
Use caution if renal dysfunction 
May cause a postive Coomb's test without hemolysis
Safety and efficacy have not been established in children
IV infusion should be given over a 30 min period

Mechanism of Action

Inhibits cell wall synthesis (bactericidal)

Pharmacodynamics

Metabolism: N/A
Half-life: N/A
Elimination: N/A

Dosage

Children:  

N/A

Adults:

500-2000 mg IV/IM q12h

Dose VS renal function

Cr. clearance (ml/min):
N/A

Dialysis
Hemo: N/A
CAPD: N/A