CEFACLOR

Antibacterial activity

Cephalosporins, second generation
Effective against some gram-negative
Gram-positive coverage 
Limited anaerobic coverage

Pregnancy Risk Factor

Class B

Contraindication/Precaution

Hypersensitivity to cefaclor, other cephalosporins or any component
Use caution if previous penicillins hypersensitivity:  10% of patient may have cross-hypersensitivity to cephalosporins
Use caution with nursing mothers
Use caution if seizure disorder
Use caution if renal dysfunction or if other nephrotoxic agents present
Use caution if history of ATB related colitis
Safety and effectiveness for use in infant <1 month old have not been established Mechanism of Action Inhibits cell wall synthesis (bactericidal) Pharmacodynamics Metabolism: only partially in vivo Half-life: 0.6-0.9 hours, changes with renal function Elimination: excreted mostly in urine Dosage Children: (max 1 g/day) >28 days old: 
20-40 mg/kg/d PO div tid

Adults:

250-500 mg PO q8h

Dose VS renal function

Cr. clearance (ml/min):
<10: unchanged 10-50: unchanged 50-80: unchanged >80: unchanged

Dialysis
Hemo: 250-500 mg PO q8h