CEFTIBUTEN

Antibacterial activity

Cephalosporins, third generation
Effective against most gram-negative 
Limited gram-positive coverage (eg. Strep pneumonia/pyogenes)

Pregnancy Risk Factor

Class B

Contraindication/Precaution

Hypersensitivity to ceftibuten, other cephalosporins or any component
Use caution if previous penicillins hypersensitivity:  10% of patient may have cross-hypersensitivity to cephalosporins
Use caution with nursing mothers
Use caution if seizure disorder
Use caution if renal dysfunction or if other nephrotoxic agents present
Use caution if history of ATB related colitis
The safety and efficacy in infant <6 months of age have not been established Mechanism of Action Inhibits cell wall synthesis (bactericidal) Pharmacodynamics Metabolism: kidney Half-life: 2 hours, changes with renal function Elimination: excreted in urine and feces Dosage Children: (max 400 mg/day) > 6 months old: 
9 mg/kg/d PO div qd-bid 

Adults:

400 mg PO qd

Dose VS renal function

Cr. clearance (ml/min):
5-29: 2.25 mg/kg or 100 mg PO q24h
30-49: 4.5 mg/kg or 200 mg PO q24h
>50: unchanged

Dialysis
Hemo: 400 mg or 9 mg/kg x1 post dialysis
CAPD: N/A