Saturday, November 19, 2011


Antibacterial activity

Cephalosporins, first generation
Gram-positive cocci (except ORSA/MRSA and enteroccocus species)
Gram negative bacilli ( E. coli, klebsiella, p. mirabillis)

Pregnancy Risk Factor

Class B


Hypersensitivity to cephradine, other cephalosporins or any component
Use caution if previous penicillins hypersensitivity:  10% of patient may have cross-hypersensitivity to cephalosporins
Use caution with nursing mothers
Use caution if renal dysfunction or if other nephrotoxic agents present
Use caution if history of ATB related colitis
Safety and efficacy in children <9 month of age have not been established Mechanism of Action Inhibits cell wall synthesis (bactericidal) Pharmacodynamics Metabolism: N/A Half-life: 1-2 hours, changes with renal function Elimination: excreted in urine Dosage Children: (max 4 g/d) > 9 months old:
25-100 mg/kg/day PO div q6-12h

Adults: (max 4 g/day)

Bacterial infections:
250-500 mg PO q6-12h

Dose VS renal function

Cr. clearance (ml/min):
<10: 125 mg PO q6h 10-50: 250 mg PO q6h 50-80: unchanged >80: unchanged

Hemo: N/A 

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