POLYMYXIN B + BACITRACIN + NEOMYCIN

Antibacterial activity

Polymyxin B: effective against gram-negative (eg: P. aeruginosa)
Bacitracin: effective against a variety of gram-positive cocci and bacilli
Neomycin: effective against aerobic gram-negative/gram-positive bacillus, anaerobic coverage

Pregnancy Risk Factor

Class C

Contraindication/Precaution

Hypersensitivity to polymyxin B or bacitracin or neomycin or any component
Safety and effectiveness in children have not been established

Mechanism of Action

Polymyxin B:  behave as cationic, surface-active compounds that disrupt the permeability of both the outer and the cytoplasmic membranes of gram-negative bacteria.
Bacitracin: inhibits bacterial cell wall synthesis
Neomycin: interferes with bacterial protein synthesis by binding to 30S and 50S ribosomal subunits

Pharmacodynamics

Metabolism: N/A
Half-life: N/A
Elimination: N/A

Dosage

Topical:

Children and adults:
apply qd-qid

Ophthalmic: ointment

Children and adults:
apply 2 cm ribbon  OS/OD q3-8h

Dose VS renal function

Cr. clearance
N/A

Dialysis
Hemo: N/A
CAPD: N/A