Amantadine inhibits the replication of influenza A virus isolates from each of the subtypes, i.e., H1N1, H2N2 and H3N2.
Pregnancy Risk Factor
Hypersensitivity to amantadine, or any component
Not recommended with nursing mothers
Use caution if heart failure or cardio-vascular disease
Use caution if seizure disorder
Use caution if renal/liver dysfunction
The safety and efficacy of amantadine in newborn infants and infants below the age of 1 year have not been established.
Mechanism of Action
Not clearly understood. Prevent the release of infectious viral nucleic acid into the host cell by interfering with the function of the transmembrane domain of the viral M2 protein. In certain cases, prevent virus assembly during virus replication.
Half-life: 10-28 hours, changes with renal function
Elimination: excreted in urine
>1 to 9 years old:
4.4-8.8 mg/kg/day (max: 150 mg/ day)
9-12 years old:
200 mg PO qd
200 mg PO qd or 100 mg PO bid
Dose VS renal function
Cr. clearance (ml/min):
<10: give q7days
Hemo: 200 mg q7days