CEFUROXIME

Antibacterial activity

Cephalosporins, second generation
Effective against some gram-negative
Gram-positive coverage 
Anaerobic coverage (no B. fragilis coverage)

Pregnancy Risk Factor

Class B

Contraindication/Precaution

Hypersensitivity to cefuroxime, other cephalosporins or any component
Use caution if previous penicillins hypersensitivity:  10% of patient may have cross-hypersensitivity to cephalosporins
Use caution with nursing mothers
Use caution if seizure disorder
Use caution if renal dysfunction or if other nephrotoxic agents present
Use caution if history of ATB related colitis
Safety and effectiveness for use in children <3 months old have not been established Mechanism of Action Inhibits cell wall synthesis (bactericidal) Pharmacodynamics Metabolism: partially, in the liver Half-life: 1-2 hours, changes with renal function Elimination: excreted in urine Dosage Children: (PO: max 1 g/day, IV/IM max 6 g/day)) >3 months old: 
IM/IV: 75-150 mg/kg/d IM/IV div q8h (200-240 mg/kg/d div q8h for meningitis)
PO: 10-15 mg/kg PO bid

Adults: (max 6 g/day)

IV: 750-1500 mg IM/IV q8h or 100-150 mg/kg/d div 6-8h
PO: 125-500 mg PO q12h

Dose VS renal function

Cr. clearance (ml/min):
<10: PO: 250 mg q24h; IV: 750 mg q24h 10-50: q8-12h 50-80: unchanged >80: unchanged

Dialysis
Hemo: 750 mg post dialysis
CAPD: 15 mg/kg post dialysis