Antifungal activity

against Aspergillus sp. and Candida sp.
Indicated for the treatment of invasive aspergillosis in patients where renal impairment or toxicity precludes the use of amphotericin B deoxycholate and in patients with invasive aspergillosis where prior amphotericin B deoxycholate therapy has failed
Also active in vitro against other fungi.

Pregnancy Risk Factor

Class B

Contraindication/Precaution

Hypersensitivity to amphotericin , or any component
Anaphylaxis has been reported; facilities for cardiopulmonary resuscitation should be available
Should not be use while nursing
Use caution if impaired renal function
Overdose has been reported to result in cardiorespiratory arrest.

Mechanism of Action

Fungistatic or fungicidal depending on the concentration in body fluids and the susceptibility of the fungus. 
Acts by binding to sterols in the cell membrane of susceptible fungi with a resultant change in membrane permeability allowing leakage of intercellular components. 

Pharmacodynamics

Metabolism: N/A
Half-life: ~30 hours, changes with renal function:
Elimination: excreted in urine

Dosage

Children and Adults: (max: 7.5 mg/kg/day)

3-4 mg/kg IV qd (infuse at  rate of 1 mg/kg/hour)

Dose VS renal function

Cr. clearance (ml/min):
<10: give q24h 10-50: give q24h 50-80: give q24h >80: give q24h

Dialysis
Hemo: none
CAPD: give q24h