Sunday, November 13, 2011


Antibacterial activity

Effective topical treatment for superficial dermatophytosis (Tinea corporis/cruris/pedis)
Active against Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum, Trichophyton tonsurans

Pregnancy Risk Factor

Class B


Hypersensitivity to butenafine , or any component
Only for topical use (not ophthalmic, vaginal, or internal routes)
Use caution if patients are known to be sensitive to allylamine antifungals should,  since cross-reactivity may occur in 1%
Use caution if nursing mother
Safety and efficacy in pediatric patients below the age of 12 years have not been studied

Mechanism of Action

Hypothesized to act by inhibiting the epoxidation of squalene, thus blocking the biosyntheses of ergosterol, an essential component of fungal cell  membranes


Metabolism: liver
Half-life: biphasic
initial: 35 hours
terminal:  >150 hours
Elimination: excreted in urine


Topical 1% cream

Children >12 years and Adults:

Cover affected and immediately surrounding skin
Tinea pedis: 
apply bid for 7 days or qd for 4 weeks 
Tinea corporis:
apply qd for 2 weeks
Tinea cruris:
apply qd for 2 weeks

Dose VS renal function

Cr. clearance (ml/min):

Hemo: N/A

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