CEFOPERAZONE

Antibacterial activity

Cephalosporin, third generation
Effective against gram-negative 
Gram-positive coverage 
Anaerobic coverage (no B. fragilis or C. difficile coverage)

Pregnancy Risk Factor

Class B

Contraindication/Precaution

Hypersensitivity to cefoperazone, other cephalosporins or any component
Use caution if previous penicillins hypersensitivity:  10% of patient may have cross-hypersensitivity to cephalosporins
Use caution if lactating
Use caution if renal/liver dysfunction or if other nephrotoxic agents used
Use caution if history of ATB related colitis
Safety and efficacy have not been established in children

Mechanism of Action

Inhibits cell wall synthesis (bactericidal)

Pharmacodynamics

Metabolism: N/A
Half-life: 2 hours, changes with hepatic function
Elimination: excreted mostly in bile, also in urine

Dosage

Children: (not approved)

100-150 mg/kg/day IM/IV div bid-tid (max: 12g/day)

Adults: (max 12-16 g/day, 4 g/day if hepatic dysfunction))

Mild to moderate infections:
1-2 g IM/IV q12h
Severe infections:
 2-4 grams IM/IV q8h or 3-6 g IM/IV q12h

Dose VS renal function

Cr. clearance (ml/min):
N/A

Dialysis
Hemo:  N/A
CAPD: N/A