CEFONICID

Antibacterial activity

Cephalosporins, second generation
Effective against some gram-negative
Gram-positive coverage 
Anaerobic coverage (no B. fragilis coverage)

Pregnancy Risk Factor

Class B

Contraindication/Precaution

Hypersensitivity to cefonicid, other cephalosporins or any component
Use caution if previous penicillins hypersensitivity:  10% of patient may have cross-hypersensitivity to cephalosporins
Use caution with nursing mothers
Use caution if renal dysfunction or if other nephrotoxic agents present
Use caution if history of ATB related colitis
Safety and effectiveness for use in children have not been established

Mechanism of Action

Inhibits cell wall synthesis (bactericidal)

Pharmacodynamics

Metabolism: none in vivo
Half-life: 4.5 hours, changes with renal function
Elimination: excreted  in urine 

Dosage

Children:

Dosage has not been established.

Adults:

Bacterial infections:
05-2 g IM/IV qd
Prophylaxis: 
1 g IM/IV x 1 given  before surgery

Dose VS renal function

Cr. clearance (ml/min):
<5: 3-4 mg/kg IM/IV q3-5days 5-9: 4-15 mg/kg IM/IV q3-5days 10-19: 4-15 mg/kg IM/ IV q48h 20-39: 4-15 mg/kg IM/ IV q24h 40-59: 8-20 mg/kg IM/IV q24h 60-79: 10-25 mg/kg IM/IV q24 >80: unchanged

Dialysis
Hemo: none
CAPD: N/A