CARBENICILLIN

Antibacterial activity

Indicated for treatment of serious urinary tract infections and prostatitis caused by susceptible gram-negative aerobic bacilli

Pregnancy Risk Factor

Class B

Contraindication/Precaution

Do not use if  hypersensitivity to carbenicillin, other penicillin or any component
Use with caution in patients with history of hypersensitivity to cephalosporins

Mechanism of Action

Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin binding proteins (PBPs)

Pharmacodynamics

Metabolism: N/A
Half-life: 1-1.5 hours, changes with renal function
Elimination: excreted in urine

Dosage

Children:(max 2-3 g/day)

30-50 mg/kg/day PO div q6h

Adults:

382-764 mg PO q6h

Dose VS renal function

Cr. clearance (ml/min):
<10: give q24-48h 10-50: give q12-24h >50: unchanged

Dialysis
Hemo: N/A
CAPD: N/A