Saturday, November 19, 2011


Antibacterial activity

Cephalosporins, first generation
Gram-positive cocci (except ORSA/MRSA and enteroccocus species)
Gram negative bacilli ( E. coli, klebsiella, p. mirabillis)

Pregnancy Risk Factor

Class B


Hypersensitivity to cefazolin, other cephalosporins or any component
Use caution if previous penicillins hypersensitivity:  10% of patient may have cross-hypersensitivity to cephalosporins
Use caution if seizure disorder
Use caution with nursing mothers
Use caution if renal dysfunction or if other nephrotoxic agents present
Use caution if history of ATB related colitis
Safety and effectiveness for use in infants <1 month of age have not been established, but still widely use nonetheless Mechanism of Action Inhibits cell wall synthesis (bactericidal) Pharmacodynamics Metabolism: N/A Half-life: 1.8-2 hours, changes with renal function Elimination: excreted in urine Dosage Children: (max 6 g/d) Body weight < 2000 g 0-7 days old: 20 mg/kg IM/IV q12h 8-28 days old:  20 mg/kg IM/IV q12h Body weight > 2000 g
0-7 days old: 20 mg/kg IM/IV q12h
8-28 days old: 20 mg/kg IM/IV q8h
> 28 days old: 25-100 mg/kg/d IM/IV div q8h 

Adults: (max 12 g/d)

Bacterial infections:
250-1000 mg IM/IV q6-12h
0.5-1 g IM/IV x 1

Dose VS renal function

Cr. clearance (ml/min):
<10: q24-48h 10-50: q12h 50-80: unchanged >80: unchanged
Hemo: 05-1 g IM/IV post dialysis
CAPD: .05 g IM/IV q12h

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