CEFAMANDOLE

Antibacterial activity

Cephalosporins, second generation
Effective against some gram-negative
Gram-positive coverage 
Anaerobic coverage (no B. fragilis coverage)

Pregnancy Risk Factor

Class B

Contraindication/Precaution

Hypersensitivity to cefamandole, other cephalosporins or any component
Use caution if previous penicillins hypersensitivity:  10% of patient may have cross-hypersensitivity to cephalosporins
Use caution with nursing mothers
Use caution if renal dysfunction or if other nephrotoxic agents present
Use caution if history of ATB related colitis
Safety and effectiveness for use in prematures and infant <1 month old have not been established Mechanism of Action Inhibits cell wall synthesis (bactericidal) Pharmacodynamics Metabolism: N/A Half-life: 0.5-1 hours, changes with renal function Elimination: excreted mostly in urine and some found in bile Dosage Children: (max = adult dose) >28 days old: 
50-150 mg/kg/day IM/IV div q4-8h

Adults:

Bacterial infections:
500-1000 mg IM/IV q4-8h
Life-threatening infections: 
2 g IM/IV q4h

Dose VS renal function

Cr. clearance (ml/min):
<10: 1 g IM/IV q12h 10-50: unchanged 50-80: unchanged >80: unchanged

Dialysis
Hemo: N/A
CAPD: N/A