CEFMETAZOLE

Antibacterial activity

Cephalosporins, second generation
Effective against some gram-negative
Gram-positive coverage 
Anaerobic coverage

Pregnancy Risk Factor

Class B

Contraindication/Precaution

Hypersensitivity to cemetazole, other cephalosporins or any component
Use caution if previous penicillins hypersensitivity:  10% of patient may have cross-hypersensitivity to cephalosporins
Use caution with nursing mothers
Use caution if renal dysfunction or if other nephrotoxic agents present
Use caution if history of ATB related colitis
Safety and effectiveness for use in children have not been established

Mechanism of Action

Inhibits cell wall synthesis (bactericidal)

Pharmacodynamics

Metabolism: partially in the liver
Half-life: 1.2 hours, changes with renal function
Elimination: excreted mostly in urine 

Dosage

Children:

Dosage has not been established.

Adults:

Bacterial infections:
1-2 g IV q6-12h
Prophylaxis: 
1-2 g IV x 1 given 30-90 min before surgery, repeat 8 and 16 hours later

Dose VS renal function

Cr. clearance (ml/min):
<10: 1-2 g IV q48h 10-50: 1-2 g IV q16-24h 50-80: 1-2 g IV q12h >80: unchanged

Dialysis
Hemo: dose post dialysis, 1-2 g IV q48h
CAPD: N/A