CLOTRIMAZOLE

Antifungal activity

Effective treatment for topical candidiasis, Tinea corporis/cruris/pedis/versicolor
Active against Candida sp., tinea versicolor due to Malassezia furfur, Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis.

Pregnancy Risk Factor

Class B

Contraindication/Precaution

Hypersensitivity to clotrimazole , or any component
Only for topical use (not ophthalmic)
Use caution if nursing mother
Safety and effectiveness of clotrimazole lozenges (troches) in children <3 years of age have not been established Mechanism of Action Binds to phospholipids in the fungal cell membrane altering cell wall permeability resulting in loss of essential intracellular elements Pharmacodynamics Metabolism: N/A Half-life: N/A Elimination: excreted in urine and feces Dosage Topical 1% cream/lotion/solution Children and Adults: Cover affected and immediately surrounding skin Tinea multiple forms:  apply bid  Candidiasis cutaneous: apply bid Oral (Troches) Children > 3 years and adults:
TX: 10 mg PO 5x/day for 14 days
Prophylaxis: 10 mg PO 3x/day

Vaginal:

Children >12 years and Adults:
cream: apply intra-vaginaly qhs for 7 days
vaginal suppository: 100 mg/day for 7 days or 500 mg single dose

Dose VS renal function

Cr. clearance (ml/min):
N/A

Dialysis
Hemo: N/A
CAPD: N/A