CLINDAMYCIN

Antibacterial Activity

Cover gram-positives and most anaerobes

Pregnancy Risk Factor

Category B

Contraindication/Precaution

Hypersensitivity to clindamycin or any component
Can cause pseudomembranous colitis and reversible liver enzyme elevation, do not give if previous pseudomembranous colitis or hepatic impairment

Mechanism of Action

Inhibits protein synthesis by reversibly binding to 50S ribosomal subunits 

Pharmacodynamics/Kinetics

Metabolism: 
liver
Half-life: 
1.6-5.3 hours, average: 2-3 hours
Elimination: 
others or unknown

Dosage

Children: IV

Body weight < 2000 g 0-7 days old: 5 mg/kg IV q12h 8-28 days old: 5 mg/kg IV q8h Body weight > 2000 g
0-7 days old: 5 mg/kg IV q8h
8-28 days old: 5 mg/kg IV q6h
> 28 days old:  7.5 mg/kg IV q6h or 5-6 mg/kg PO q8h

Adults:  

PO: 150-300 mg q6h
IV: 300-900 mg q6-8h (max 2.7 g DIE)

Dosage In Renal Failure

Creatinine clearance (ml/min):
<10: unchanged 10-50: unchanged 50-80: unchanged >80: unchanged